Endocrine Abstracts

Glucocorticoids have profound effects on bone leading to glucocorticoid-induced osteoporosis observed at long term steroid therapy. The glucocorticoid receptor (GR) is a hormone-induced transcription factor controlling gene expression as a monomer or dimeric molecule. We demonstrated- in contrast to the prevailing view - that the induction of genes by dimeric GR molecules suppresses inflammation in disease models. In contrast the monomer GR mediates inhibition of bone formatio...

Glucocorticoids have profound effects on bone leading to glucocorticoid-induced osteoporosis observed at long term steroid therapy. The glucocorticoid receptor (GR) is a hormone-induced transcription factor controlling gene expression as a monomer or dimeric molecule. We demonstrated- in contrast to the prevailing view - that the induction of genes by dimeric GR molecules suppresses inflammation in disease models. In contrast the monomer GR mediates inhibition of bone formatio...

Glucorticoids (GCs) belong since their discovery to the standard therapy of rheumatoid arthritis (RA), a severe auto-inflammatory bone disease. One major side effect of GCs affects the skeleton itself leading to GC induced osteoporosis (GIO), the most secondary osteoporosis.To optimize anti-inflammatory therapies utilizing steroids a profound understanding of GC action on the interface of inflammation and skeletal integrity is required.<p class="abst...

Insulin resistance and obesity are a global health problem and directly linked to macrophage-driven inflammation of the adipose tissue. Glucocorticoid therapy, used to treat inflammatory conditions, increases adiposity and insulin resistance. It is unknown however, whether anti-inflammatory actions of glucocorticoids at physiological levels can have beneficial effects on adipose tissue inflammation, potentially limiting insulin resistance. Using a macrophage specific deletion ...

Glucocorticoid signalling is essential during embryonic lung development, with both the global and epithelial glucocorticoid receptor (GR) null mice presenting with lung atelectasis and post natal lethality. In this study, we examined the role of glucocorticoid signalling within mesenchymal tissues. To study the role of the GR in mesenchymal tissues during embryogenesis we crossed GRflox mice with Dermo1-Cre mice to generate GRDermo1 mice, where the GR gene was cond...